This study reveals a highly promising method for constructing single-atom nanozymes, particularly well-suited for applications in the biomedical field, such as glucose detection. Traditional noble metal nanozymes often present challenges related to biological toxicity or high costs in these applications. While Fe-based nanozymes exhibit lower biological toxicity, their preparation typically involves high-temperature conditions and intricate procedures. In this research, a novel approach was introduced by using plant extracts as precursors to coordinate single iron atoms, successfully achieving the synthesis of FeN/GQDs single-atom nanozymes. This method not only simplifies the synthesis process but also significantly reduces its complexity. The resulting FeN/GQDs single-atom nanozymes not only demonstrate outstanding peroxidase-like enzyme performance but also exhibit remarkably high sensitivity in glucose detection. This study offers new insights into designing single-atom nanozymes, advancing the synthesis of safe and cost-effective nanozymes. This promising strategy holds great potential for diverse applications in biosensing and various biomedical fields.
